Sequencing.com recensione 2025

Sequencing.com Overview: Outsmart Your Genes One App at a Time

Conventional DNA tests like AncestryDNA and 23andMe analyze less than 0.1% of your total DNA. For a more extensive understanding of your health and ancestry, it’s essential to encompass your entire genome.

Sequencing.com provides advanced DNA sequencing that furnishes 50-100% more genetic data than standard alternatives. Through this test, you unlock access to lots of comprehensive reports encompassing your ancestry, health, and overall wellness.

You don’t need specialized genetics knowledge to navigate Sequencing.com; the platform is designed to be user-friendly and cost-effective. Read on to learn about my experience trying this brand.

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How Sequencing.com Works

What’s in the Box: An introductory letter, cheek swab collection tube with specimen bag, registration/instruction card, and a prepaid mailing envelope with tracking number.

The kit comes with everything you need to get started, including a prepaid mailing envelope.

Activate the Test: Before you swab your cheeks, you’ll need to activate your DNA collection kit. If you don’t activate your kit, the lab won’t be able to start work on the sequencing process, so this is important. There’s a QR code to make this step easy.

Taking the Test: There’s no blood or saliva required, just some harmless little cheek cells. Before you take the swab, you should wash your mouth with water first and spit it out to help clean your mouth. 

Be sure to avoid drinking (anything other than water), eating, smoking, brushing your teeth, or using mouthwash, at least 60 minutes before you take your cheek swab sample. 

I highly recommend following the instruction card provided – it includes a link with a how-to video to ensure you get a high-quality cheek swab sample. You’ll essentially need to rub the heck out of your cheek (one or both) to collect a decent amount of skin cells. It might hurt a little (it did for me), but at least you’ll know you have a good sample.

There’s a very helpful video tutorial to ensure you get the best cheek swab sample.

Mailing and Time to Results: Once you’ve finished collecting your sample, put it back in the test tube, apply the kit ID labels as instructed, and seal it up in the specimen bag. Then it’s time to put it in the prepaid shipping envelope and send it on its way. Depending on which bundle you choose, the time to results could be anywhere between 2-8 weeks – you’ll receive an email from Sequencing.com when your results are ready to view.

Upload your raw DNA files with Sequencing.com’s Upload Center. You can even upload data from multiple tests – the highest quality data will be combined using One Genome technology.

Raw DNA Uploads (Optional): You have the option to either await the results of your Sequencing test or, if you’ve previously undergone a DNA test and have access to your raw DNA data, you can upload it to Sequencing.com. Each testing site provides instructions on how to obtain your raw DNA data. If you don’t have previous test data, that’s perfectly fine. However, if you do, Sequencing.com will utilize its One Genome technology to amalgamate the highest quality data from each raw DNA file, potentially enhancing the accuracy of your reports.

Sequencing.com Products and Services

Sequencing.com sets itself apart by providing a lot of flexibility, allowing you to choose precisely the information you wish to explore from its extensive range of apps and reports. Depending on your membership tier, you can access both free and premium apps spanning various categories, with the platform regularly adding new options.

Privacy and data security are paramount at Sequencing.com. Your personal information and DNA data are carefully protected and kept confidential. They are never sold or shared with any third parties, unless you opt to share them with a healthcare provider or family member for specific purposes.

A Brief Overview of How the Apps Function: These apps automate the process by analyzing your raw DNA data and compiling detailed reports, making the information more accessible and easier to understand. Some apps may take longer to process your data, while others generate results more quickly. I advise trying out a few apps and engaging in other activities while waiting, as it can be a lengthy process. You’ll receive an email notification once the results are ready from each app.

You can easily filter the large selection of apps and reports available. 

Ancestry

Although you can’t dig very deep on Sequencing at this time, there are some great ancestry-related apps to help you learn more about your family’s origins.

Featured Apps in this Category:

• Map My Genes – See where people with a similar genetic makeup are located
• Ancestry & Genealogy – Learn more about the origins of your DNA
• World Ancestry Report – Uncover your global connections using advanced analysis

The EDGC Ancestry & Genealogy app (shown below) did a decent job compared to previous tests I’ve taken, but I wouldn’t consider it spot-on – it was more vague, for one; I suspect due to a smaller user database. The European bit is reasonably close compared to 23andMe and AncestryDNA; those tests both say I’m approximately 99% European. However, 23andMe says my “slice” of Middle Eastern/African/Asian is less than 1%, and this app said it was nearly 9%. So, I question the accuracy here until I have my whole genome data to compare it to. So, take this information with a grain of salt or try multiple DNA tests to see how they measure up.

There’s also no way to connect with relatives or build a family tree (at least, not yet), but it’s something that’s in the works for a future Sequencing.com update.

EDGC’s Ancestry & Genealogy breakdown was more vague compared to other DNA tests I’ve taken.

Other Tests to Consider

• AncestryDNA is still king when it comes to doing genealogical research – its user database of 18,000,000+ users is the largest currently available, and chances are you’ll find lots of relatives already on the site. Its major downside: Its subscription-based memberships are very expensive – one year can cost about the same as a one-time fee for a whole genome sequencing test.
• FamilyTreeDNA lets you find matches for free, but its user database of ~1,150,000 doesn’t even compare to Ancestry’s (although it is growing all the time). It does offer something Ancestry doesn’t: in-depth maternal and paternal DNA tests that dig deeper than a standard autosomal (familial) DNA test.

Health and Wellness

You’ll find several apps and reports that can help you determine which diseases and conditions you may have a risk of developing or passing on to your children. These reports can also help you be more proactive to live a healthier life.

Featured Apps in this Category:

• Wellness and Longevity – Predict, prevent, and prevail with actionable health reports
• Disease Risk Genetic Test Report – Learn your genetic risk factors for your risk of cancers, heart disease, autoimmune diseases, and more
• Vitamins DNA Wellness Report – Find out where your vitamin levels could use a little boost based on your genetic makeup
• Blood Traits and Conditions – Learn how your genes could impact your vascular health

Bioinformatics

Warning: this section is not for the faint of heart. This area is better suited to medical professionals or genetics buffs who want to understand every last strand of their DNA (like yours truly).

Featured Apps in this Category:

• Genome Explorer – The browser for your genes – shows every snippet of your DNA by chromosome, condition, and more
• Genome Overview - A technical overview of your genetic data

Now, you can try and interpret your raw data in Genome Explorer like I did, but the apps and reports basically exist to do the work for you, saving you a lot of time, unwarranted panic, and confusion. It also helps if you view individual apps/reports and then look up the details in the explorer to ”see” it for yourself.

If you do want a little guidance, Sequencing offers genetic counseling through the Genetic Counseling by DNAVisit app, which provides 60 days of online chat with a licensed genetic counselor who can help you understand your results and answer any questions. The service is included in the Professional Genome Plan at no additional cost (if you’re on that plan, you can buy the report from the Genetic Counseling Marketplace, and a credit will be applied automatically).

A glimpse at the Genome Explorer – it’s confusing, but with a little guidance, I can see how my body responds to aspirin based on my DNA.

I did a quick example here (pictured above) to show you how Genome Explorer works. I knew what to expect because my Wellness and Longevity report told me that, based on my DNA, my response to aspirin should be normal (it is). So, I pulled up the related data in the explorer to see how my genes play into aspirin response efficacy/toxicity. I don’t have any genetic variants or risks (referred to as “alt” in the explorer) that could indicate the potential for aspirin resistance, thankfully.

This is just a very simple example; your potential to develop diseases or rare conditions is often based on numerous genetic markers and variants covering numerous genes, and fair warning – trying to do further research might make your head spin. Also, unless you get whole genome sequencing done, you won’t know all of your genetic risks beyond the most common ones (this is where the most popular DNA tests fall very short). Even then, you may never develop a condition just because your genes indicate a higher risk, so it’s best to consult with a medical professional if you see something alarming to you.

Lifestyle

Your DNA can tell you loads about your lifestyle, including how well you may (or may not) sleep, and even how the weather might affect your mood.

Featured Apps in this Category:

• Sleep DNA Wellness Report – Restless sleeper? Early riser? Night owl? This report can reveal your sleep-related answers
• Cannabis DNA Health Report – Find out which cannabis strains can help your body function optimally or potentially cause problems
• Thrive – Find balance through healthy eating, stress reduction, and exercise tailored to your needs

Children

If you decide to test your child’s DNA, you can review important health reports that may affect their well-being, along with fun facts you’ll both enjoy.

Featured Apps in this Category:

• Prevent Sudden Death – See if your child has risk factors for SIDS or other causes of sudden death
• Brain Health: Mental Health & Mood – Learn what makes your child tick, including seasonal, biochemical, and stress-related factors
• Santa and Me – How much DNA does your child have in common with Jolly Ol’ Saint Nick?

Diet and Fitness

Nutrition

One diet doesn’t fit all; these apps and reports can help you determine which foods are best for you based on your genes, and where your diet might be lacking.

Featured Apps in this Category:

• DNA Diet – Find out how your unique DNA affects your metabolism, appetite, and more
• Lactose Intolerance – Do dairy products cause you intestinal discomfort, or is it something else?
• Nourish – Personalized strategies for optimal health and dietary habits
• Nutrigenomics: Nutrition Analysis – Learn which vitamins, minerals, and food sensitivities might be affecting your diet

Fitness

Are you built for strength or endurance? Find out how your DNA could impact your ability to lose weight, build muscle, and improve your overall health through exercise and healthy habits.

Featured Apps in this Category:

• Athletic Performance – Find out which sports and activities can help your body thrive
• RunDNA – See which type of training and lifestyle habits can optimize your distance running performance
• Empower – Learn which types of exercise and recovery methods are best for your body

I gave the Athletic Performance app a spin, and the report confirmed what I knew from personal experience – I’m a power athlete rather than someone who can handle endurance-based exercise. You’ll never see me run a marathon, that’s for sure, and I was a sprinter back in my school days. This also falls into line with what AncestryDNA and 23andMe’s health reports told me, so I’d say this data is pretty accurate.

My actual results from the Athletic Performance report – it’s true, I’m more of a power athlete than an endurance-based one. Strong and short sprints, no marathons!

Beauty

Find out how your DNA could affect your risk of developing skin conditions and the ability to keep a full head of hair.

Featured Apps in this Category:

• Genetic Risk of Hair Loss – Are you doomed to lose your hair? This app can help you plan ahead.
• Melanoma Skin Cancer Prevention – Find out if you’re at risk for melanoma, a deadly form of skin cancer, and how to minimize your chances of developing it
• Skin Genes – Keep your skin in optimal shape with skincare suggestions based on your unique DNA

Art

Mostly just for fun, and for the time being, includes just two apps.

Featured Apps in this Category:

• DNA Selfie Appearance Predictor - See how your DNA might dictate your facial appearance
• DNA Art – Order unique artwork inspired by your DNA

I tried the selfie appearance predictor just for fun. Thankfully, it was free with my trial membership, because had I paid for the results I got, I would have felt cheated. As shown in the image below, I got a pretty laughably wrong “best prediction” for mine – I’m most certainly not blonde, nor is my hair shade light. (I did have reddish-blonde hair for a time when I was a baby, though.)

Results from the DNA Selfie Appearance Prediction app – its best guess was wrong!

To be fair, the probability charts show what you might look like, and there are only so many options, but clearly they aren’t 100% error-proof. I highlighted the traits that do describe me: I have hazel-brown eyes, my hair is dark brown, and my skin is more intermediate-pale. That combo does appear in the potential guesses, so I can’t fault the app too much, but definitely prepare to laugh at how wrong it could be. Or maybe you’ll get lucky and it will nail your traits on the first try. To compare, 23andMe and AncestryDNA guessed my traits pretty accurately.

Similar Tests to Consider

SelfDecode – Some of SelfDecode’sreports appear in the Sequencing app store, and you can save a bit of money by running them through Sequencing rather than paying for individual reports or a membership on SelfDecode’s site. If you want additional insight toward living a healthy life, though, SelfDecode can help you further “hack” into your DNA with its own rich database of genetic data and personalized lifestyle recommendations.

EverlyWell – You’ll find a variety of test kits on EverlyWell that let you test specific areas like vitamin levels, thyroid function, metabolism, and more. It’s a good way to monitor your health over time, while a DNA test only checks for genetic components that could affect these measurements.

Pricing: Free and Paid Options for Beginners and Advanced Users

Membership Plans

Sequencing.com offers free and paid subscription plans to suit any type of user.

All plans include:

• Privacy Forever Protection
• HIPAA Compliant Data Security
• Unlimited Secure Storage
• One Genome Technology

Free

• Next Gen Disease Screen (100 Conditions)
• Genome Explorer (Bioinformatics data)

Plus 

• Next Gen Disease Screen (1,000 Conditions)
• Genome Explorer (Disease + Bioinformatics data)
• $5 monthly report credits
• Ability to purchase proprietary reports, including Genetic Ancestry with Haplogroups, Map My Genes Archaeology Edition, and Map My Genes

Premium

• Sequencing AI (including unlimited chat and 2 reports/month)
• Health Scan
• Next Gen Disease Screen (16,000 Conditions + Monthly Updates)
• Genome Explorer (Health Interpretation + All Other Data)
• $10 monthly report credits
• Ability to purchase proprietary reports, including all reports in Plus, as well as 13 others

Professional

• Sequencing AI (including unlimited chat and 5 reports/month)
• Health Scan
• Next Gen Disease Screen (16,000 Conditions + Weekly Updates)
• Genome Explorer (Health Interpretation + All Other Data)
• Health Scan
• Free Genetic Counseling
• Dedicated Support Expert
• $20 monthly report credits
• Ability to purchase proprietary reports, including all reports in other plans + Genome Overview

Your data won’t be deleted at the free membership level – you can store your information on its servers indefinitely for free. You can also opt in to share your DNA data with genetics researchers – your data is de-personalized to ensure your privacy. 

Note: Monthly membership fees vary depending on which tier you’re on.

DNA Test Kits

Sequencing only offers one test, the 30X Whole Genome Sequencing. This kit is available in different bundles, depending on your needs. For example:

• WGS Health Screen Bundle
• WGS Comprehensive Health Bundle
• WGS Professional Health Bundle

Sequencing’s WGS Health Screen Bundle and WGS Comprehensive Health Bundle both come with a free month of Premium membership to help you get a feel for everything it has to offer. WGS Professional Health Bundle includes one month of Professional membership. 

All bundles come with free shipping, although the processing is quicker for the more expensive options and you’ll get more health reports included, too.

Accepted Payment Methods

Sequencing accepts payments from all major credit and debit cards, HSA/FSA cards, plus “Buy Now, Pay Later” options including Affirm, Afterpay, and Klarna (for domestic US orders only).

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Sequencing.com Customer Support: Useful Information, but Hard to Find

Website

Depending on where you look, help can be a bit confusing to find on the Sequencing website. You will, however, find a very thorough knowledge base, education center, and contact links under the Support menu. You can also search for answers and submit support tickets via the Contact Support link.

Social Media

You can technically reach support staff via social media (X, Facebook, and LinkedIn), although I found this was the slowest and least effective way to get answers.

Individual App Support

As for app support, most feature a quick explanation, pricing info (if applicable) and a FAQ on each individual app page. This is especially helpful since many apps are maintained by third-party developers and not Sequencing.com staff.

My Support Experience

I was curious about the age range for taking Sequencing.com’s DNA tests, since other test kits state users must be at least 13 years old and under adult guidance. This answer came pretty quickly via support ticket (thanks, Hannah). I learned the tests can be done by users of any age, as long as the primary account holder is at least 18 years old.

A response to my inquiry was very prompt as a registered member of the site.

I submitted a second support ticket when the question I asked via Facebook didn’t warrant a good response. Hannah was able to tell me there aren’t any limitations as to where DNA kits are shipped, they ship worldwide without any restrictions.

Support tickets are by far the fastest way to get answers.

My help experience on Facebook didn’t quite work out. Not sure if Hannah handles that or not – the canned response mentioned her name, but I didn’t hear back for several days, and still didn’t get a definite answer until I submitted another support ticket. So, I recommend going the support ticket route.

On Facebook, I got a canned response right away, but never got a definitive answer to my quick question. (I eventually got my answer via support ticket #2.)

Although Facebook support fell a bit short for me, I did receive an email asking me to rate my support ticket experience, which was positive. So, don’t feel discouraged if you don’t get a good response via social media – filling out a support ticket via the website is your best bet, and they’ll keep your ticket open until you’re a satisfied customer.

Final Verdict: It’s Worth Getting Your Sequencing in Order

Do I think it’s worth bringing Sequencing.com into your life? Yes. The extra bits of information you can unlock with its DNA sequencing can tell you much more than 23andMe does about important health and wellness topics. (Although, if you reside in the United States, it’s due to strict FDA rules that 23andMe and AncestryDNA can’t tell you everything they might know about your health.)

Who would I recommend Sequencing.com to? If you’re someone who wants to take better control of your health and doesn’t mind the steep learning curve that goes into interpreting your DNA, you’ll get a lot of value out of Sequencing.com’s Genome Explorer app. I also recommend Sequencing if you have complicated health issues or a history of disorders that could use better clarity through whole genome sequencing and a consultation with a genetic counselor.

Do you need to crack open a biology or genetics book to understand your DNA? Maybe, although no matter how much you do or don’t remember about DNA, there are loads of helpful resources to help you figure out each of the apps featured on Sequencing.com. These apps mainly exist to help you make heads or tails of the data – in other words: each app does the heavy lifting for you by processing your DNA, then spits out the relevant data in a more digestible format.

A handful of apps are a bit more vague, offering generic suggestions of lifestyle changes, fitness, and eating plans based on the collective data from users with a similar genetic makeup. Other reports are extremely thorough and more personalized, especially the ones available from App MD. The App MD reports tell you which variants in your genes are related to certain traits and conditions, along with citations of studies relating to those topics. I recommend choosing its reports first if you’re on a plan that offers 2 or more free reports each month.

Want an even bigger challenge? Try browsing the millions of characters of raw DNA data yourself, but beware, your head may explode due to the sheer volume of data. This is one notable drawback to the site for me: I have a pretty good foundation of what DNA is all about, but I would appreciate a more comprehensive tutorial on how to use the Genome Explorer app so I can work out which data is most relevant and which parts are simply DNA fluff. A video tutorial or user workshop would be extremely helpful. It does become clearer as you learn which genes contain the most commonly-referenced markers, but you’ll need some patience if you want to dig deeper without an expert geneticist’s supervision.

That said, Sequencing might not be for you if you want a more standard overview of your health or a novelty list of traits, something that sites like Ancestry.com offers. Although sites like Ancestry are starting to upcharge for “premium” health-related reports, and you could potentially get this information for much less with a free or lower-level Sequencing.com membership.

I would also like to see a wider variety of apps on Sequencing. It approves new ones regularly (and removes apps that aren’t up to snuff), but the selection is kind of sparse in categories such as Ancestry, Fitness, and Art. Some apps also appear under more than one category, which lends itself to further confusion. Why offer these “departments” unless they’re filled with lots of choices instead of just a couple novelty reports? In comparison, Helix offers a similar “app store” format of DNA reports, yet it features even fewer free apps, plus a very limited selection of premium health and wellness apps, some at a much higher cost than what you can get from Sequencing.

I’m confident that over time, Sequencing’s app offerings will grow and improve as more researchers and app developers get on board. After all, this kind of freely available, deep genetic data is still in its early stages, not to mention how time-consuming and costly it is to process each person’s entire genome.

Overall, I’m pretty pleased with my Sequencing.com experience. I learned new health-related information that I plan to follow up on with my doctor. I also like that I can keep all of my raw DNA data on the site, should I ever want to upload/download it elsewhere. I previously had my raw data stored on my computer, which isn’t a terribly stable or secure method in the long run. I think you’ll find Sequencing’s site is ideal for keeping your DNA data safely stored in a central location you can access and share from home, the doctor’s office, and on the go. And best of all, you can help by contributing valuable data (yours) that pushes DNA research even further into the future.

FAQs

What is Whole Genome Sequencing?

Whole genome sequencing is one of the most advanced DNA testing methods available. Instead of covering less than 1% of the most common genetic markers (which is the limited range covered by popular direct-to-consumer DNA test kits), clinical-grade genome sequencing tests 100% of your DNA and genetic code. Due to its complexity and cost, large-scale genome sequencing isn’t offered as widely as mainstream DNA tests. Thanks to advancements in genetic research in recent years, though, the cost is going down rapidly, making sequencing a more viable option for everyday consumers and healthcare practitioners. This means what once cost thousands of dollars is now less than 1000 U.S. dollars in most cases.

Is Genome Sequencing the Same as a DNA Test?

Both tests are similar in how you submit a DNA sample (with a saliva or cheek swab sample), but they are not exactly the same. Each type of test requires different techniques to crack into your DNA code.

Standard DNA tests, like the ones offered through ancestry websites, use a process called genotyping, which covers less than 1% of your DNA (typically around .01 to .02% – not even half of a percent). An efficient and cost-effective method, genotyping covers the most common genetic variants shared among humans, but it isn’t as thorough as whole genome sequencing. Genotyping works well for everyday users, especially those researching genealogy and people who are curious about common traits and general health issues.

Whole genome sequencing, on the other hand, involves a more rigorous testing process and covers 100% of your genetic code. Sequencing allows researchers and doctors to take a deeper look at how all of your genes, not just a small sample, could influence your overall health and wellness. It can uncover multiple risk factors and unique genetic variants genotyping tests barely cover or skip over altogether. This makes sequencing more expensive, yet it’s a more accurate testing method, especially if you have or might be a carrier of rare diseases and genetic defects standard DNA tests aren’t designed to detect.

Is Genome Sequencing Safe?

Yes, clinical-grade genome sequencing is very safe. Although DNA testing companies are not regulated by the FDA, they employ advanced medical and security standards to ensure your DNA sample and genetic data is always safe and sound. Kit processing labs are CLIA-certified (Clinical Laboratory Improvements Amendments) and CAP-accredited (College of American Pathologists), plus your data is stored using strict Health Insurance Portability and Accountability Act (HIPAA) guidelines. Many are also GDPR and Privacy Shield Compliant.

Your lab sample is identified by a kit ID number, no personal information is connected except through your personal account portal – a private link is supplied to you when testing is complete.

As an added measure of security and privacy, if you decide to share your DNA raw data with genetic researchers, it is stripped (aka depersonalized) of your personal information. Additionally, your information is not sold or shared with third-party companies, insurance companies, or marketers.

Is Genome Sequencing Accurate?

Sequencing is the most accurate way to screen all of your DNA. The more your test kit covers, the more data researchers and doctors can learn about your unique genetic makeup. To compare, a typical DNA genotyping kit covers about .01-.02% of your DNA. Sequencing.com’s 30X Whole Genome Sequencing covers 100% of your DNA.

Who Should Take a Whole Genome Sequencing Test?

If you enjoy a generally healthy lifestyle with minimal issues, you may not need a whole genome sequencing test. You can learn plenty of useful, actionable data from a standard DNA test without digging deeper.

On the other hand, if your family has a history of poor health or rare diseases and birth defects, you can gain a wealth of valuable information from a whole genome sequencing test. There’s no guesswork involved – every genetic marker and variation is covered, which can help both you and your doctor make more informed healthcare decisions. The data can also prove valuable to medical researchers as they work to pinpoint the causes and treatments for rare cancers and genetic disorders, among other issues.

What is the Best DNA and Whole Genome Sequencing Service?

Overall, you can get a great deal of value out of a Sequencing.com membership. Depending on your membership level, you’ll have access to numerous free and premium reports each month, plus you can purchase additional reports based on your needs and interests from a variety of independent genetic app providers. 

This app store approach, which features reports from carefully vetted app developers, also gives you better control over the information you can choose to unlock. Plus, you can upload, download, and store your genetic data indefinitely, and for free, even without a paid membership. 

Other whole genome sequencing services, such as Dante Labs and Nebula Genomics, also offer a wealth of information, yet don’t support raw DNA uploads from as many providers as Sequencing.com. Nebula Genomics offers more ancestry-focused reports than Sequencing.com, though, so if you’re researching deep ancestry, you may have better luck with Nebula. Dante Labs, on the other hand, is mainly focused on health and wellness reports, making them a solid choice if you’re trying to develop better eating and fitness habits based on your DNA.